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What the published research reported A phase-2 randomized trial published in the New England Journal of Medicine in 2023 studied retatrutide in adults with obesity and reported substantial, dose-dependent reductions in body weight over 48 weeks, alongside a gastrointestinal side-effect profile broadly similar to other incretin drugs

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Evidence Tier Framework Tier 1 FDA-approved therapy large randomized trials Tier 2 human trials demonstrating biological effect Tier 3 small human studies or limited clinical data Tier 4 animal models or anecdotal reports Stacking should generally involve: at least one Tier 1 therapy no more than one Tier 3 compound Stacks composed entirely of Tier 34 compounds should not be considered clinical protocols

The Lancet (2021) 5

But most peptides sold online are promoted for unproven uses, often combined in stacks, to purportedly heal injuries, build muscle, rejuvenate skin or increase energy