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Including melatonin, folinic acid, and sulforaphane in the treatment plan for individuals with autism can complement other therapies and interventions targeted at addressing specific symptoms and improving overall quality of life

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Conventional epigenetic drugs, such as HDAC inhibitors or DNMTi, broadly alter chromatin states and often exhibit substantial off-target effects, limiting their suitability for treating depression or addiction in a targeted manner 196

Further, the concentration of free metal ions in in vivo is thought to be very low as iron and other metals are sequestered by various metal binding proteins [94]