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doi: 10.1016/j.cvsm.2021.01.008 233

Genes not in the above categories and potential relationship to CVS The main limitation of using the paroxysmal, or any, model of CVS to determine a gene list for in-depth analyses is that there may be genes that do not correspond to the hypothesis, but nonetheless constitute some of the genetic predisposition towards the development of disease

Crucially, In the ARKI animals the AR-dependent transcriptional activity was impaired in the epididymis and there was an absence of receptor SUMOylation linking this PTM to normal male reproduction and fertility (179)

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