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Takahashi S, Harigae H, Ishii KI, Inomata M, Fujiwara T, Yokoyama H, Ishizawa K, Kameoka J, Licht JD , Sasaki T, Kaku M

They are associated with larger tumor size, lymph node involvement, and the presence of distant metastases, all of which contribute to a poor prognosis (62)

Prostate 55 , 187193 (2003)

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Inhibition of epithelial SHH signaling exerts a dual protective effect against inflammation and epithelial-mesenchymal transition in inflammatory bowel disease