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Ferreira LM, Hebrant A, Dumont JE (2012): Metabolic reprogramming of the tumor

Additionally, these reactive species induce DNA oxidation, leading to mitochondrial and nuclear DNA mutations, further impairing ATP production and exacerbating ETC dysfunction

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Moreover, miR-25, a specific miRNA, can suppress the expression of microphthalmia-associated transcription factor (MITF), a crucial transcription factor in melanogenesis, thereby modulating the process of melanogenesis