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Similarly, in intestinal epithelial cells from IBD patients, excessive ER stress induces increased trypsin-like activity, which activates protease-activated receptors 2 and 4, disrupting barrier function and increasing intestinal permeability [89]

Peripheral blood and leukocyte concentration of vitamins The concentration in plasma showed deficiency in three of the four vitamins analyzed

Three weeks after transduction with AAV, the serum levels and liver lysate of human hepsin were confirmed and quantified via ELISA and western blot following the administration of the same dose of AAV-hHPN WT , AAV-hHPN RS or AAV-EGFP (Fig

Liposomal delivery helps preserve the active form and supports improved intracellular availability

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