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Throw it away and apply a patch at your next scheduled time

One 2022 pilot study (n = 24) found modest improvement in skin brightness (+8 % L* value) after eight weeks of topical application

High retinol intake during pregnancy poses teratogenic risks to the developing foetus

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Some medications can reduce the absorption of vitamin B12 including me dull, tobramycin, gentamicin, and other medications such as tributyl antihistamines