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SKU: 14884795479
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Because the Munc13-4-binding domain in STX7 is conserved yet unique to STX7, ENDOs are predicted not to interfere with other SNAREs, consistent with data showing ENDOs do not inhibit neutrophil exocytosis, which requires SNAP-23, STX4, STX6, VAMP1 and VAMP2 (refs

Bodo C Melnik and Gerd Schmitz contributed equally to this work

doi: 10.1046/j.1365-2133.1998.02115.x

When multiple circuitries break down, patients come close to a point-of-no-return in which health appears definitely lost and therapeutic interventions appear likely impossible (Lpez-Otn and Kroemer, 2021)