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Description

Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL

World Patent WO2024003359A1 (2023)

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In some ways, the lesser degree of obesity and exacerbated metabolic disturbances in these mice resembles the clinical characteristics of Asian patients with T2DM 17,18 , suggesting that Insr P1195L/ +/HFD mice are suitable for investigating the pathophysiology of HFD-sensitive T2DM in humans