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For example, when cultured in selenium-deficient conditions, Jurkat cells (a human T cell model) exhibit increased spontaneous cell death [18], due to decreased expression of selenium-dependent antioxidant enzymes (i.e., selenoproteins) such as glutathione peroxidases (GPx) and thioredoxin reductases leading to excessive oxidative stress and eventually cell death

Endocr Relat Cancer 27:245259

Androgen deficiency: Cases of androgen deficiency have occurred with use of opioids for an extended period of time (see CLINICAL PHARMACOLOGY)

EBioMedicine 98 , 104851 (2023)

Remove the Mask: After the recommended time, gently peel off the mask and discard it