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Under oxidative stress, Nrf2 is released from Keap1 and translocated to the nucleus, where it binds to the antioxidant response element (ARE) and upregulates the expression of NQO1 and HO-1 (Meng et al., 2014)

Finally, all authors read and agreed with the eventual manuscript

NAC is assumed to act as a disulfide bond reducer, scavenger of reactive oxygen species, and precursor of glutathione biosynthesis

doi: 10.1016/j.ijid.2023.08.019 186 PerlisRHSantillanaMOgnyanovaKSafarpourATrujilloKLSimonsonMDet al

We therefore performed secondary screening for these genes by generating in-frame deletions using lambda red recombineering and assessing the resulting phenotypes