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The American Heart Association includes CRAO in its definition of an acute ischemic stroke, a sudden episode of neurological dysfunction caused by a lack of blood flow to the brain, spinal cord, or retina

IJMS 26:4353

Howsoever, the synthesis of 3-HK from Kyn by the flavoprotein kynurenine-3-monoxygenase (KMO) is another critical point in the Kyn pathway, determining the balance between the neurotoxic component 3-HK and the neuroprotective KYNA [216]