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The results revealed improved stability, bioactivity, and cytotoxicity against the MCF7 cell line [99]

6 Conclusion Current evidence indicates that Curcuma longa and its bioactive compounds may offer potential benefits in alleviating symptoms of depression and anxiety in patients with chronic diseases, particularly those with metabolic dysfunction-associated conditions (DACD)

All animal handling procedures were carried out in strict accordance with the Animal Welfare guidelines approved by the Institutional Ethics Committee and Research Advisory Committee of the Mashhad University of Medical Sciences, Iran (code: IR.MUMS.PHARMACY.REC.1400.010)

23 , 24 To function effectively, it requires large amounts of oxygen in the tumor microenvironment (TME), which is unfortunately hypoxic

Evolution of the metazoan TrxR appears to have been brought about by extension of the C-terminal protein coding sequences of the gene, leading to acquisition of the new C-terminal active site (Novoselov and Gladyshev, 2003)