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3.4.2 - Naive T cell depletion Several groups have posited that GVHD pathogenesis is driven largely by alloreactive naive T cells and hypothesized that selective depletion of CD45RA+ naive T cells may reduce GVHD while retaining GVL, a strategy that has been applied to HSCT with encouraging results ( 3.4.3 - Treg depletion There is considerable evidence in both mice and humans that prevalence of CD4+CD25+ regulatory T cells (Tregs) is associated with protection from GVHD, and these cells may play an important role in mitigating GVHD pathogenesis through control of effector T cell alloreactivity (151)

1 Introduction The gut microbiome consists of bacteria, archaea, viruses, and eukaryotic microbes that colonize the digestive tract

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