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The different pivot for tilting of RL (the inner pillar cells) compared with the pivot of TM (its insertion in the spiral limbus, Figure 1) generates a gap during the tilting of both membranes, which is considered the main drive for endolymph to move SC of both OHC and IHC during radial shearing

While youre not likely to run into MPTP (unless youre taking synthetic street drugs), it is chemically similar to a commonly used herbicide called paraquat.[ref] Subsequently, a number of studies have shown that higher paraquat exposure increases the risk of Parkinsons disease.[ref] Monoamine Oxidase increases ROS: When monoamine oxidase breaks down a monoamine (neurotransmitters, tyramine, etc.), the reaction produces hydrogen peroxide and possibly ammonia, which are reactive oxygen species (ROS)

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Parkinson's disease: an overview of current treatment options

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