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Table 1, Fig

Moreover, by integrating Limited Proteolysis-Small Molecule Mapping, western blotting and siRNA-based functional assays, we identify that uridine binds to poly(rC)-binding protein 1, thereby suppressing ferroptosis and preserving mitochondrial function

The ROS scavenging property of Sp was also replicated in the Drosophila models knocked-down for essential antioxidant enzymes catalase and glutathione peroxidase, where neuronal cells of 15 days AEL flies genetically expressing a redox biosensor, roGFP showed reduced fluorescence under Sp treatment (Fig

Biochem Biophys Res Comm 185:2935 Gipp JJ, Bailey HH, Mulcahy RT (1995) Cloning and sequence of the cDNA for the light subunit of human liver -glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues