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Targeted therapies

Research demand from institutions across the UAE and GCC continues to grow alongside the regions expanding interest in regenerative biology and tissue repair research

*Correspondence: Yuexin Yu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

One of the most debilitating and defining hallmarks of ME/CFS and Long COVID is post-exertional malaise (PEM), a severe, disproportionate exacerbation of symptoms following even minor physical, cognitive, or emotional exertion

However, several studies that have assessed the effects of one night's sleep deprivation on the HPA axis have shown that cortisol secretion is either not or minimally affected by sleep following prolonged wakefulness (65-67)