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The incretin hormones GLP-1 and GIP (targeted by semaglutide and tirzepatide respectively) regulate postprandial insulin secretion and suppress appetite via central mechanisms forming the basis of GLP-1 receptor agonist pharmacotherapy

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At high or sustained doses, these enzymes become saturated, leading to a buildup of free pyridoxine in the plasma

While both vitamins play individual roles, they also interact with each other

Reactive oxygen species - sources, functions, oxidative damage