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On the other hand, zinc is not merely an essential cofactor for key antioxidant enzymes such as Cu/Zn-SOD

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In PD there is slow destruction of dopaminergic neurons in the substantia nigra, resulting in reduced dopamine levels in the brain ( Neurotrophic factors like glial cell-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) have emerged as possible agents to promote dopaminergic neuron survival and function in preclinical PD models ( 3.3 Huntington's disease (HD) HD is caused by a mutation in the Huntingtin protein, which results in the aggregation of this protein in the neurons of HD patients ( 4 Targeting blood-brain barrier by nanoparticles The blood-brain barrier (BBB) functions include supplying the brain with nutrients, protecting it, and preserving ionic equilibrium to maintain brain architecture and integrity

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In cuprizone-rats, BPC 157 was given per-orally in the same regimen that may rescue rats with severe ulcerative colitis and colon-colon anastomosis