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In addition to its impact on epithelial cells, such as intestinal epithelial stem cells, H 2 O 2 is also implicated in the pathogenesis of inflammatory bowel disease [300]

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

171 Although research into brain stimulation is in its early stages, case reports of successful treatment using stimulation to the brain cortex or deeper brain structures indicate the potential for this method to be helpful in patients with severe tinnitus that has not responded to other therapies

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