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To date, a number of CoV vaccines have been licensed for use in domestic animals against canine CoV, feline CoV, bovine CoV (BCoV), porcine epidemic diarrhoea virus, transmissible gastroenteritis virus (TGEV) and infectious bronchitis virus (IBV) 2

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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)

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