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doi: 10.1038/nm.4106 236 ReyndersTDevolderLValles-ColomerMVan RemoortelAJoossensMDe KeyserJet al

Since high levels of GSTs are expressed in the hepatocytes and it has previously been demonstrated that GSTs display sulfonamidase activity, three sulfonamide prodrugs of metformin were designed and synthesized 120

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However, acaricide resistance, drug residues, environmental pollution, health disorders and other side effects have been inadvertently caused by certain acaricides currently in use 18 , and acaricide residues further threaten the safety of animal-derived food