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Recipients with antibody-mediated rejection exhibit reduced gut microbial richness and diversity, accompanied by significant changes in key metabolites, such as 3-hydroxy-5-cholic acid and taurocholic acid, both of which correlate strongly with microbial compositional shifts [168]

doi: 10.3389/FCHEM.2021.651053 100 ShestovskayaMVLussALBezborodovaOAMakarovVVKeskinovAA

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The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity, and tumorigenesis

Although the use of exosomes as a delivery system has its drawback (for example, quickly eliminating by the reticuloendothelial system, lack of efficient encapsulation methods, and potential immune responses), exosomes targeted at tumors may allow systemic administration of miRNA as cancer treatment and are thus worthy of attention