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(5.11, 12.2) Interaction with Methotrexate: Concomitant use with PPIs may elevate and/or prolong serum concentrations of methotrexate and/or its metabolite, possibly leading to toxicity

Addiction Biology, 23(1), 7083

We found that the ebselen could significantly promote SGN survival, decrease SGN apoptosis, and reduce intracellular ROS levels after peroxynitrite exposure in vitro , while the deficiency of GPX1 led to opposite patterns of the above effects