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Furthermore, durability and minimal wear-debris generation are critical factors affecting clinical viability (Bowles and Setton, 2017

Every growth spurt means new bone, muscle, and skin cellsall requiring DNA synthesis (folinic acid). Every cold and infection triggers rapid immune cell multiplication (folinic acid). Meanwhile, their brain is still under constructionforming connections, building nerve insulation, producing neurotransmitters for learning and mood (methylfolate)

The glial scar, a dense limiting border outside the injury site, is the primary cause of the failure in axonal regeneration, and reducing glial scar formation after SCI contributes to the regrowth of transected axons (Yang et al., 2020)