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Serum UA concentration depends on the amount of purines consumed, UA biosynthesis, excretion/reabsorption of UA in the kidneys, and secretion of UA in the intestine [11](Fig

Finally, one could request that the laboratory parse out a direct LDL-C from the blood sample

Here are some things to consider when taking creatine supplements: You have no family history of male/female pattern baldness You're not currently experiencing hair loss Your hair is thick with no signs of thinning The performance benefits outweigh theoretical concerns You're already at Stage I on the Norwood scale with no progression Multiple family members experienced early hair loss You're already showing signs of thinning (Ludwig Scale Grade II or higher) You're currently losing more hair than normal You're on the Norwood Scale Stage III or beyond You have other risk factors for androgenetic alopecia Start with a conservative dose (3-5g daily) Monitor your hairline and crown carefully Take progress photos every 4-6 weeks Discontinue if you notice changes Iron deficiency Insufficient protein intake Vitamin D deficiency Biotin deficiency Thyroid disorders Autoimmune conditions (alopecia areata) Hormonal imbalances Chronic stress Extreme calorie restriction Crash dieting Lack of sleep High physical or emotional stress Tight hairstyles (traction alopecia) Excessive heat styling Chemical treatments Over-washing or harsh products Monitor Your Hair: If you have started taking creatine and notice increased hair loss, consider stopping and see if the shedding reduces

FEBS Lett 1998