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The expression of these cytokines heightens the influx of neutrophils into the joint fluid, followed by an increased inflow of monocytes

Animal studies have shown that these effects may be mediated through key signaling pathways such as PI3K/Akt, SIRT1/Nrf2, and AMPK/PGC-1, thereby enhancing testicular steroidogenesis and antioxidant capacity, among other benefits, and mitigating reproductive damage induced by diabetes, obesity, radiation, and environmental toxins

For example, transcription factors play an important role in regulating transcription by binding to specific recognition sites on the chromosome, often at a genes promoter, and interacting with other proteins in the nucleus

Med Chem Res 34 , 22472268 (2025)