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Elevated Gal-3 levels have been observed in PLWH compared to uninfected controls, suggesting ongoing myocardial fibrosis and inflammation ( 3.5 Cardiac electrophysiological risks in HIV-associated cardiomyopathy Importantly, PLWH are also at increased risk for electrophysiological abnormalities, including QT interval prolongation and Brugada-pattern electrocardiographic changes, which contribute to a heightened risk of sudden cardiac death ( QT prolongation in HIV may be multifactorial, driven by chronic inflammation, ART effects, electrolyte imbalances, and direct myocardial involvement

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There are no conclusive data concerning the effect of ascorbic acid on SOD activity in cells under physiologic conditions

In the long-term extension to 52 weeks, those continuing treatment maintained VAT reductions of approximately -18%