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Prog Neurobiol 85(3):297317

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In research settings, it is studied for its involvement in angiogenesis, cellular repair mechanisms, and the modulation of inflammatory pathways in experimental systems

Activated microglia will in turn release pro-inflammatory cytokines (TNF-, IL-1 and IL-6), colony-stimulating factor 1 (CSF1), brain-derived neurotropic factor (BDNF), reactive oxygen species (ROS) among others into the spinal cord micro-environments, to direct multidirectional crosstalk between primary afferent, interneurons, secondary neurones, astrocytes and microglia