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Scripts and full datasets are available at github.com/FertigLab/hypoxiaROSanalysis with DIO reference 10.5281/zenodo.12640998 RNA sequencing and analysis of CTCs Whole blood was harvested from NSG female mice bearing MDA-MB-231 hypoxia fate-mapping orthotopic tumors

However, there were noticeable side effects when the maximum doses were used

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Thus, we generated pRE-1 and pRE-2 constructs by cloning the 791 bp (739 to +51) and 808 bp (+3493 to +4300) fragments containing these putative p53-binding elements, which were then fused with SV40 promoter, and inserted into the pGL3 luciferase reporter vector