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Mechanistically, L2HG acts as a metabolic-epigenetic regulator that inhibits 2-oxoglutarate-dependent dioxygenases, induces histone hypermethylation, and remodels chromatin accessibility to activate an ATF3-dependent transcriptional program

Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver

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228 CCND1 is the G1/S checkpoint of the cell cycle, and reduced expression of CCND1 is associated with G1 phase arrest

coli BL21 were co-transformed with the pEVOL-pBpF plasmid and the expression plasmid carrying the respective Munc18-1 amber mutant