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Since animal studies have demonstrated a close link between glutathione and glutamate uptake into both microglia and astrocytes, and NMDA receptor function, we also predicted that glutathione and glutamate levels in the brain would be correlated across all subjects

Autophagy 16 , 5269 (2020)

But todays hectic lifestyle makes it hard to achieve that ideal balance, and some underlying medical problems or even day-to-day stresses can interfere with antioxidant production

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Without oxidative stress, cysteine and cystine appear to essentially mediate cellular stress via thiols other than GSH (Rahman and MacNee, 2000