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Glucose-6-phosphate will metabolically trifurcate into the following pathways: (i) conversion to fructose-6-phosphate by the enzyme phosphoglucose isomerase, entering the glycolytic pathway, or (ii) oxidation by glucose-6-phosphate dehydrogenase to 6-phosphogluconolactone, thereby initiating the oxidative phase of the pentose phosphate pathway

Newer, more specific PET tracers, such as those targeting cyclooxygenase enzymes (COX-1/2), monoamine oxidase B (MAO-B), the purinergic P2X7 receptor, colony stimulating factor-1 (CSF-1), 7 nicotinic receptors and cannabinoid 2 receptors and phosphodiesterase 4B (PDE4B) should allow for more precise characterization of neuroimmune signaling [350,351,352]

Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

2.1.3 TAMs and macrophage polarity Tumor-associated macrophages (TAMs) are a kind of innate immune cell in cancers

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