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Guevara et al

If HCPCS codes are added to an APC and, after recalibrating its relative payment weight, holding its unadjusted copayment amount constant results in an increase in the coinsurance percentage for the reconfigured APC, the copayment amount would be calculated as the product of the payment rate of the reconfigured APC and the lowest coinsurance percentage of the codes being added to the reconfigured APC

It is also, notably, the same property that makes systemic dosing worth scrutinizing: a molecule whose defining feature is carrying copper is a molecule whose systemic use has to be evaluated in light of how the body already manages copper

We acknowledge BioRender ( for the production of the figures in the article