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deacetylation of PGC-1 mitochondrial biogenesis SIRT3 (mitochondrial): deacetylation of mitochondrial enzymes better OXPHOS efficiency SIRT6 : stabilization of telomeres, DNA repairs SIRT2 : regulation of metabolism and the cell cycle Sirtuin activation is the main longevity mechanism associated with NAD+

"Glutathione and mitochondria." Frontiers in Pharmacology, 2014

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Moderate Responders (3 to 6 weeks): Chronic injuries and more severe damage often require this longer timeframe to show significant improvement

8,60,61 Thus, individuals with fibromyalgia may benefit from periodic blood testing to assess various inflammatory biomarkers to monitor the course of their illness and response to treatment