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Additionally, while AOD-9604 demonstrated excellent safety in the studied populations, individual medical histories may reveal contraindications or concerns requiring careful evaluation

Oral Administration (if applicable): For oral formulations of AOD-9604 , research has shown bioavailability of approximately 40% in animal studies

Total: 80 mg

GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord

In this article, Abba Kastin and colleagues review the known effects of DSIP and argue that further work is needed before it can be considered functional