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Dahan, A., Miller, J.M., Hoffman, A., Amidon, G.E., Amidon, G.L., The solubility-permeability interplay in using cyclodextrins as pharmaceutical solubilizers: mechanistic modelling and application to progesterone, J

Gut 61 (6), 829838

No further undesirable effects are to be expected when the prescribed dosage regimen is followed correctly

This is the minimum timeframe for meaningful change, consistent with the clinical trial data

However, further optimization work is needed, using expanded training sets of compounds and thorough validation of liver cell models, before the in vitro comet assay could be incorporated in the standard battery for genotoxicity testing