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In general, unlike other types of NP (including those induced by trauma and diabetes) axonal degeneration in peripheral nerves is not present in CIPN (Ji et al., 2013)

Future Phase III trials (e.g., ongoing photoaging studies) may further clarify its utility [12]

In melanoma, the upregulation of GPX3 plays a role in regulating ROS levels by inhibiting the expression of HIF-1 and -2 (50)

Seleninic or selenol intermediates generated from the oxidation/reduction of DSePA can follow the analogous catalytic steps as discussed for the native GPx enzyme in the earlier section to detoxify the hyperoxides by consuming the thiols [82, 83]

[Organic and Biomolecular Chemistry, 2003, vol