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The Zn 2+ -deficient/Cu 2+ -SOD1 WT and fALS WTL SOD1 mutants were shown to efficiently oxidize ascorbate, with a subsequent reoxidation of SOD1-Cu + by oxygen to produce O 2 , which combines with NO afterward to produce peroxynitrite 35

Studying changes in the less affected tissue (BA9) and the primarily affected brain region (CAU) provided insights into the diseases progression

In the case of SpFN-elicited RBD-targeting mAbs, we divided them into two broad epitope categories targeting either (i) the hACE2-binding site (Group A RBD mAbs, associated with class I), or (ii) a conserved cryptic site (Group B RBD mAbs, associated with class III/V)

Schwarz R, Grossman AR (1998) A response regulator of cyanobacteria integrates diverse environmental signals and is critical for survival under extreme conditions