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Free radicals mediate the mitochondrial membrane depolarization and release of cytochrome C which in turn activate and induce the apoptosis process.114,115 A single study has reported the protective role of melatonin against vancomycin-induced nephrotoxicity in comparison with other important antioxidants.116 Intraperitoneal administration of vancomycin 10mg/kg, for 7 days, severely enhanced the serum creatinine, urea and malondialdehyde (MDA) levels which indicated the impaired renal function and cellular injury

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The correlation between the species-specific standard redox potentials and the species-specific thiolate protonation constants is depicted in Fig

Abdelnour et al

This morphological change is not observable when lentivirus-treated cells are coincubated with an anti-SVCT2 antibody (to stimulate endocytosis of the transporter), with the inhibitor quercetin, or when the glucose transporter GLUT1 is overexpressed, which incorporates the oxidized form of vitamin C, DHA (Salazar et al., 2016)