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Ethics declarations Competing interests The author Hong-Shuo Sun is a member of the Editorial Board of the journal Acta Pharmacologica Sinica, but he has not been involved in the peer-review or decision-making process for this manuscript

At 36 h after PEG treatment, 6,994 DEGs were identified between LY46 and HGN, with 3,687 upregulated and 3,307 downregulated

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Finally, we calculated the F statistics before MR analysis, and all SNPs were greater than 10, suggesting the strong instruments of IVs (37)

Elevated Gln/Glu was also found in the frontal cortex of the Gclm / mouse relative to controls [82, 84], which is further accentuated by social isolation stress after weaning [76]