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Loras C, Gisbert JP, Mnguez M, Merino O, Bujanda L, Saro C, et al

Ipamorelin Dosing Schedule (Community-Derived) Phase Assessment Timing Week 1 Daily Dose 100 mcg/day Frequency 1x at bedtime, fasted Phase Titration Timing Weeks 2-3 Daily Dose 200 mcg/day Frequency 1x bedtime, or split 100 mcg AM + 100 mcg PM Phase Standard Timing Weeks 4-8 Daily Dose 200-300 mcg/day Frequency 1-2x daily (AM fasted + bedtime is common) Phase Extended Timing Weeks 9-12 Daily Dose 200-300 mcg/day Frequency Continue if tolerated

Recommendations for monitoring are as follows: Surveillance for 2 years to determine the need for systemic therapy (taking into account the fact that many patients present spontaneous remission)

Its important to remember that dietary triggers are not the same for everyone

Laboratory evaluation typically shows elevated TSH, low free thyroxine (fT4), and increased TPOAb titers, while thyroid ultrasound reveals diffuse hypoechogenicity and heterogeneous parenchymal texture