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The metabolic pathways for the homocystinurias (HCU) and methylmalonic acidemias (MMA) are very confusing

More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

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Since CSF entry correlated with plasma concentration and plasma half-life, [4] a route that lowers the plasma peak should lower central exposure further still

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