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Diet and Lifestyle: In conjunction with injections, dietary adjustments or oral supplementation may be considered to maintain adequate vitamin B12 levels, especially in dietary-related deficiencies

Moreover, we found that Hcy induced neurodegeneration-like pathological changes in mitochondria in the brain via the inhibition of the NAD + /Sirt1 pathway, including defects in mitochondrial morphology, mitochondrial biogenesis, and mitophagy, ultimately leading to impairments in synapses and cognition, all of which were reversed by Ndufa1 upregulation

Vegans and vegetarians, for example, are at a higher risk of B12 deficiency because the main sources are animal products like meat, fish, and dairy

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