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10.1016/j.celrep.2017.05.077 64 ServilloL.D'OnofrioN.GiovaneA.CasaleR.CautelaD.CastaldoD.et al (2018)

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coded by GSH1 ) catalyses the first and rate-limiting step, during which dipeptide -Glu-Cys is formed from glutamate and cysteine ( GSH2 , which ligates -Glu-Cys with glycine ( S.cerevisiae (coded by GRX1-8 genes)

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Key hormonal shifts: Estrogen drops significantly, affecting mood, sleep, bone density, and tissue health Progesterone declines, impacting sleep quality and anxiety levels Human growth hormone (HGH) decreasestied to estrogen levels, HGH falls as estrogen falls Testosterone gradually decreases, affecting libido and energy These hormonal changes create cascading effects throughout the body, from hot flashes and night sweats to cognitive changes, weight redistribution, joint pain, and sexual dysfunction