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Emerging tools, such as pharmacogenetic (110) and nutrigenomic (111) tests now facilitate large-scale pharmacogenomic and nutrigenomic analyses, enabling the early identification of genetic variants that affect nutraceutical-drug interactions

Can Assoc Radiol J

Yet, excessive exercise may overwhelm these networks: chronic AMPK overactivation has been associated with impaired anabolic signaling and fatigue, while sustained mTORC1 inhibition can lead to muscle atrophy (61, 62)