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Biochem Eng J 41(3):234240

Considering these two approaches together may be relevant particularly in cases such as chronic fatigue, recurrent infections or diabetic wounds

GSH regeneration is catalyzed by glutathione reductase using GSSG and NADPH generated by the pentose phosphate pathway (PPP, also called hexose monophosphate shunt, which also produces pentose phosphate sugars used in nucleotide synthesis.) The first reaction of the PPP, catalyzed by glucose 6-phosphate dehydrogenase (G6PD), is critical for producing an adequate amount of NADPH used in reductive biosynthetic pathways and importantly in the generation of GSH