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J Nutr 134:1583S-1587S

Inspired by intracellular multi-enzyme cascade reactions, researchers initially attempted to construct artificial cascade systems by encapsulating natural enzymes within porous synthetic materials, including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and hydrogen-bonded organic frameworks (HOFs) ( 3 O 4 or Au nanoparticles), effectively resolving stability issues ( Figure 3 )