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A recent, 2-week, open-label pilot-study in 16 PD patients showed reduced plasma level variability compared to oral IR LD/CD and that DopaFuse treatment over 11 days was associated with matching OFF-time reduction and ON-time gain of 1.7 h [24]

Bile acids The circulation of bile acids (BAs) plays a crucial regulatory role in liver repair and regeneration through the livergut axis, 506,507 with impaired regenerative capacity observed following external biliary drainage

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In addition, treatment regimens were not stratified in detail, which may confound the observed associations between ICI type, irAE incidence, and outcomes