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The mRNA levels of DUSP22 are also negatively correlated with mRNA levels of the inflammatory cytokines TNF-, INF-, IL-17, and IL-10 in the intestine mucosa of IBD patients

The inhibition of methylation enzymes (DNMTs) with different molecules such as azacitidine and decitabine (drugs used in oncology), can be useful in modifying the malignant phenotype of the cells through re-expression of tumor suppressor genes [8, 47, 48]

Structural analysis of BsGGT and BlGGT demonstrated that their binding pocket is solvent exposed, as they lack lid loop or any of that sort to cover the active site